Pentosan Platinum is a concentrated anti-inflammatory and stimulant of cartilage synthesis, repair and protection.
Composition: Contains: Sodium pentosan polysulfate 250mg/ml, glucosamine 150mg/ml, hyaluronic acid 2.5mg/ml
Dosage and Administraion: Administer 6-18ml by intravenous injection as directed by a veterinary surgeon.
Features and Benefits: Sodium pentosan polysulfate (PPS) is a linear polymer prepared from xylan, a complex hemicellulose extract of the plant (Beechwood) origin. PPS is one of the sulfated heparinoid compounds. The heparin like anti-coagulant effects have been reduced and the anti-inflammatory, fibrinolytic and tissue trophic effects have been enhanced. Pentosan Platinum
actively reverses the effects of osteoarthritis in the joints via a series of actions including:
1. Stimulating Chondrocyte Metabolism: Results in increased production of proteoglycans and healthy cartilage matrix. PPS stimulates synovial fibroblasts and produces an increased amount of high molecular weight hyaluronic acid which results in an increased production of normally viscous joint fluid. Improving the fluid volume and consistency results in more effective joint lubrication and also stabilisation, which limits further cartilage damage.
2. Anti-inflammatory Activity: PPS has an inhibitory action on all mediators of the arachidonic acid cascade. PPS also inhibits the lysosomal catabolic enzymes histamine, hyaluronidase, cathepsin B, and polymorphonuclear elastase. PPS exerts a specific inhibitory effect on mediators implicated in the degradation of cartilage matrix components, preserving the cartilage and thus preventing the release of the highly inflammatory mediators, which relieves pain and inflammation.
(c) Fibrinolysis and Lipolysis: PPS is strongly fibrinolytic, stimulating the release of plasminogen activator and promotes the dissolution of thrombi and fibrin deposits in synovial tissues and subchondral blood vessels. PPS also mobilizes lipids and cholesterol in synovial and subchondral blood vessels, which have been implicated in the pathogenesis of osteoarthritis in older animals. These effects combine to increase the pre-fusion to the joint, which stimulates cartilage healing and repair. Pentosan Platinum is a very sophisticated approach to the long term management of osteoarthritis in horses. Unlike traditional treatments, the unique effects of Pentosan Platinum promote the healing and the restoration of a healthy joint, in addition to having a safe anti-inflammatory effect. Pentosan Platinum is NOT a non-steroidal anti-inflammatory drug like Phenylbutazone nor the cortisones (both of which have damaging effects on joints with prolonged use). Pentosan Platinum does not suppress joint cartilage healing and repair. Rather than simply masking the pain, PPS directly stimulates joint healing and repair.
Corticosteroids, anti-inflammatory agents and NSAIDs all relieve the symptoms of osteoarthritis but DO NOT ALTER THE DISEASE PROCESS. Both hydrocortisone and NSAIDs have a marked inhibitory effect on the biosynthesis of the components of the extracellular matrix of cartilage, which limits the early healing response of cartilage to injury.
infectious inflammatory joint disease, traumatic arthritis, osteoarthritis, degenerative cartilaginous joint disease and osteochondrosis dessicans in horses. 7 day intervals for three injections.
Pentosan Platinum articular injection.
If intra-articular use is required, administer 1mL by sterile intra-articular injection. PPS has an affinity for cartilage and active drug levels will accumulate for several days after administration. For maximum effect, tissues should be exposed to the drug over an extended period, hence the four injections. A period of improvement for up to six months following a course of four injections may be expected. If at any time during this period the horse becomes sore (e.g. following a particular activity), it is safe to administer a further injection to settle any inflammatory process.
Presentation: 18ml sterile single dose glass vial. Provides multi (1.5 g) for a 500 kg horse at the recommended dose rate (3 mg/kg).
Storage: REFRIGERATION NOT REQUIRED. Store below 25C (Air conditioning) and protect from light.
Note: Contraindications: Use in horses with clotting defects, traumatic hemhorrage, infection, renal or hepatic failure or within 48 hours of surgery.
For use as a supplemental source of Vitamins & Amino Acids in horses, cattle, sheep, swine, camels, alpacas and pigeons. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.