RED ACID is used to reduce inflammation,repair and protect joints in Racehorses, Thoroughbreds, Standardbreds and Quarter Horses. RED ACID is a concentrated anti-inflammatory and stimulant of cartilage synthesis, repair and protection (250 mg/mL).
Indications: To aid in the management of non-infectious inflammatory joint disease, traumatic arthritis, osteoarthritis, degenerative cartilaginous joint disease and osteochondrosis dessicans in horses.
COMPOSITION: Contains: 30ml sterile vial of Red Acid
Actions: Red Acid, the sodium salt of Red Acid (HA), is a non-sulphated glycosaminoglycan (GAG) which is present in many body tissues including the connective tissue and skin and in the synovial (joint) fluid in very high concentrations. HA provides visco-elastic properties to joint fluid and functions as a lubricant. In joint disease, inflammation leads to the accumulation of inflammatory cells and degradative enzymes in the joint fluid which break down HA. The loss of HA results in the lowered viscosity of joint fluid and further influx of inflammatory cells, leading to further cartilage damage and also worsening joint disease. Supplementation of red acid helps to replace HA lost as a result of joint disease and thereby restores lubrication of the joint, reduces inflammatory infiltrates and minimizes ongoing damage.
Features and Benefits: Red Acid (RA) is a linear polymer prepared from xylan, a complex hemicellulose extract of plant (Beechwood) origin. RA is one of the sulfated heparinoid compounds. The heparin-like anti-coagulant effects have been reduced and the anti-inflammatory, fibrinolytic, and tissue trophic effects are enhanced. R ed Acid actively reverses the effects of osteoarthritis in joints via a series of actions including:
- Stimulating Chondrocyte Metabolism: Results in increased production of proteoglycans and healthy cartilage matrix. RA stimulates synovial fibroblasts to produce increased amounts of high molecular weight Red Acid which results in an increased production of normally viscous joint fluid. Improving the fluid volume and consistency results in more effective joint lubrication and stabilization, which limits further cartilage damage.
- Anti-inflammatory Activity: RA has an inhibitory action on all mediators of the arachidonic acid cascade. RA also inhibits the lysosomal catabolic enzymes hyaluronidase, histamine, cathepsin B, and polymorphonuclear elastase. RA exerts a specific inhibitory effect on mediators implicated in the degradation of cartilage matrix components, preserving the cartilage and preventing the release of the highly inflammatory mediators, thus relieving pain and inflammation.
- Fibrinolysis and Lipolysis: RA is strongly fibrinolytic, stimulating the release of plasminogen activator, and promoting the dissolution of thrombi and fibrin deposits in synovial tissues and subchondral blood vessels. RA also mobilises lipids and cholesterol in synovial and subchondral blood vessels, which have been implicated in the pathogenesis of osteoarthritis in older animals. These effects combine to increase the prefusion to the joint, which stimulates cartilage healing and repair.
Red Acid is a sophisticated approach to the long term management of osteoarthritis in the horse. Red Acid is effective by intra-articular use. Unlike traditional treatments, the unique effects of Red Acid promote healing and also the restoration of a healthy joint, in addition to having a safe anti-inflammatory effect. Red Acid is NOT a non-steroidal anti-inflammatory drug like Phenylbutazone or the cortisones (both of which have damaging effects on joints with prolonged use). Red Acid does not suppress joint cartilage healing and repair. Rather than simply masking pain, RA directly stimulates joint healing and repair. Anti-inflammatory agents, corticosteroids and NSAIDs all relieve the symptoms of osteoarthritis but DOES NOT ALTER THE DISEASE PROCESS. Both hydrocortisone and NSAIDs have a marked inhibitory effect on the biosynthesis of the components of the extracellular matrix of cartilage, which limits the early healing response of cartilage to injury.
For: Horses, Camels and Dogs
Dosage and Administration: Red Acid contains medium molecular weight Red Acid of a viscosity suitable for intra-articular use. Red Acid is effective when given by intra-articular . If intra-articular is required, administer 1.5ml by sterile intra-articular . RA has an affinity for cartilage and active drug levels will accumulate for several days after administration. For maximum effect, tissues should be exposed to the drug over an extended period, hence the four uses. A period of improvement for up to six months following a course of four uses may be expected. If at any time during this period the horse becomes sore (e.g. following a particular activity), it is safe to administer a further use to settle any inflammatory process. Red Acid is particularly effective and displays synergy with concurrent use of a quality (Glucosamine and Chondroitin sulfate supplement), to provide the essential raw materials for joint repair and maintenance.
Storage: Store below 25C (Air Conditioning). This product does not contain an antimicrobial preservative and protect from light.
Note: Contraindications: Use in horses with clotting defects, traumatic hemorrhage, infection, renal or hepatic failure or within 48 hours of surgery.
For use as a supplemental source of Vitamins & Amino Acids in horses, cattle, sheep, swine, camels, alpaca, and pigeons. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Warning: Radiographic examination should be undertaken prior to administration to rule out joint fractures or advanced degenerative joint disease. When administering to the competition horse, ensure that the regulations of relevant authorities are always observed.
Tips for Trainers: Best used the day before event or extreme exercise with 4ml per joint.